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Jian-Kang Yu

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Review Open access Oct 2026

Nanotechnology-Enabled Immunotherapy for Colorectal Cancer: Overcoming the “Cold” Tumor Microenvironment in Microsatellite-Stable Disease

Background Immune checkpoint inhibitors (ICIs) have transformed the management of mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC), yet the ~95% of patients with mismatch repair-proficient/microsatellite-stable (pMMR/MSS) disease derive little benefit owing to an immunologi...

Jia-Yu Xu, Jian-Kang Yu, Gang Liu et al. · 0 citations

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