Author

Jian-Kang Zhao

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Open access Aug 2026

Beyond Carbapenemases: Chromosomal Resistance Mechanisms and Carbapenemase Type Determine Susceptibility to Novel β-Lactam/β-Lactamase Inhibitor Combinations and Cefiderocol in Carbapenem-Resistant Pseudomonas aeruginosa from China

Background: β-lactam/β-lactamase inhibitor combinations (BL/BLIs) and siderophore cephalosporin serve as critical polymyxin alternatives for carbapenem-resistant Pseudomonas aeruginosa (CRPA). However, systematic multicenter clinical data from China and the resistance mechanisms underlying non-susceptibility to these a...

Jian-Kang Zhao, Yan-Yan Fan, Bin Cao · Antibiotics · 1 citation

Open access Oct 2026

Pulmonary Disease and NF-κB-Associated Responses in Mice Infected with Two Klebsiella pneumoniae Isolates

Hypervirulent Klebsiella pneumoniae (hvKP) causes invasive disease, but pulmonary macrophage responses remain incompletely defined. We compared strain 55055, used as a classical K. pneumoniae (cKP) comparator, with strain 46274, operationally classified as hvKP, using a pneumonia model, single-cell RNA sequencing of po...

Rong-Rong Song, Jiu-Yang Xu, Dan-Ni Pu et al. · Microorganisms · 0 citations