Open access
Sep 2026
SAE1 knockdown attenuates hepatic fibrosis by promoting ubiquitination and proteasomal degradation of TGF-β receptors
Abstract Objective Liver fibrosis is characterised by excessive accumulation of extracellular matrix and can ultimately progress to cirrhosis and malignant transformation. Activation of hepatic stellate cells (HSCs), largely driven by transforming growth factor-beta (TGF-β) signalling, is a central event in fibrogenesi...
Tong Liu, Meng-Ru Wang, Guo-Liang Zheng et al.
· BMJ Open Gastroenterology · 0 citations