Molecular filler-enhanced DNA nanomachines enable one-step multiplex quantification of ctDNA for mutation analysis and metastasis-associated assessment.
Detection of low-abundance biomarkers like circulating tumor DNA (ctDNA) remains challenging for molecular diagnosis and therapeutic management of cancer. Here, we developed a homogeneous electrochemical platform using metal ion-mediated DNA self-assembly enhanced by molecular fillers, enabling simultaneous, amplificat...