Open access
Oct 2026
Kidney-directed AAV9 Klotho gene delivery improves renal function in a mouse model of chronic kidney disease.
Chronic kidney disease (CKD) is associated with progressive renal dysfunction, Klotho deficiency, and activation of profibrotic signaling. This study evaluated the functional and molecular effects of kidney-directed adeno-associated virus serotype 9 (AAV9)-mediated human Klotho delivery in experimental CKD. Forty-eight...
Chao-Ying Yan, Jian Li
· Biomolecules & biomedicine · 0 citations