Author

Jianlin Wu

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Open access Jul 2026

Structure-Based Design of New Nonpeptidic Covalent Mpro Inhibitors against SARS-CoV-2 and Omicron Variants

The main protease (Mpro) is a prime target for anti-SARS-CoV-2 drugs. Herein, we describe the structure-based covalent modifications that generate new nonpeptidic covalent Mpro inhibitors. The compounds exhibit strong inhibition against Mpro at submicromolar levels. The deuterated lead compound exhibits submicromolar...

Honglei Bao, Ling-Chen Sun, Shilin Gong et al. · ACS Bio & Med Chem Au · 0 citations

Aug 2026

Electrostatic bridge-induced aggregation of silver nanoclusters for turn-on Mn2+ detection and luminescent film fabrication.

In this work, red-fluorescent silver nanoclusters (MMTA@Ag NCs) with aggregation-induced emission (AIE) properties were synthesized via a facile one-pot strategy at room temperature using 2-mercapto-4-methyl-5-thiazoleacetic acid (MMTA) as the capping ligand. The as-prepared Ag NCs initially exhibited weak fluorescence...

Pengfei Gao, Bing Han, Guo-Mei Zhang et al. · Analytical Methods · 0 citations

Review Aug 2026

Engineering Advanced Nanomedicine Against Depression: From Treatment Challenges to Delivery Strategies.

By moving beyond generic strategies for BBB penetration to address the distinctive pharmacotherapeutic shortcomings of depression, engineered nanomedicine holds great promise for advancing next-generation antidepressant therapies that achieve rapid onset, precise intervention, and comprehensive improvement in patient q...

Mijia Zhang, En-Yao He, Y. Xiong et al. · Advanced Healthcare Material... · 0 citations