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Author

Jian-Ping Zhou

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Review Open access Oct 2026

Nanotechnology-Enabled Immunotherapy for Colorectal Cancer: Overcoming the “Cold” Tumor Microenvironment in Microsatellite-Stable Disease

Background Immune checkpoint inhibitors (ICIs) have transformed the management of mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC), yet the ~95% of patients with mismatch repair-proficient/microsatellite-stable (pMMR/MSS) disease derive little benefit owing to an immunologi...

Jia-Yu Xu, Jian-Kang Yu, Gang Liu et al. · 0 citations
Review Open access Sep 2026

Prognostic and clinicopathological value of perineural invasion in colorectal cancer: a meta-analysis

Background Perineural invasion (PNI) is a pathological feature associated with aggressive tumor behavior in several solid malignancies. In colorectal cancer (CRC), PNI has been reported to correlate with poorer prognosis, as well as increased risks of postoperative recurrence and metastasis. However, the available evid...

Xin-Yue Zhang, Jing-Tong Tang, Jian-Ping Zhou · 0 citations

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