Author

Jian-Quan Ni

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Open access Sep 2026

NAT10 governs development through the Xrp1-mediated stress response rather than its RNA acetylation activity

N4-acetylcytidine (ac4C) is installed by N-acetyltransferase 10 (NAT10) and represents the only known acetylation mark on messenger RNA. Since NAT10 also acetylates transfer RNA, ribosomal RNA (rRNA), and proteins, its in vivo molecular mechanisms remain elusive. Here, we demonstrate that knockdown of Drosophila NAT10...

Lin Wang, Zhao Xue, Shu-Yang Gao et al. · Science Advances · 0 citations

Open access Aug 2026

FOCUS-3D: Robust, generalizable volumetric cell segmentation for three-dimensional fluorescence microscopy

FOCUS-3D is introduced, a robust, broadly generalizable volumetric cell segmentation framework built on a large, diverse manually annotated cell resource and advanced AI designs that achieves state-of-the-art performance across diverse species, tissues, fluorescent reporters and imaging modalities.

Qing-Hua Zhang, Ze-Yu Mu, Bo-Qi Liu et al. · bioRxiv · 0 citations