Severe SARS-CoV-2 infection is characterized by lung hyperinflammation, impaired IFN responses, and defective T cell activation, yet the molecular drivers of these immune dysregulations remain incompletely understood. Caspase-11 (CASP11), a key effector of the noncanonical inflammasome, has been shown to mediate an inn...
M. Eltobgy, Mohamed M. Shamseldin, Owen D. Whitham et al.· JCI Insight· 0 citations
The role of the intestinal epithelium in host susceptibility and responses to SARS-CoV-2 and the influence of Paneth cells on the outcome of SARS-CoV-2 infection are addressed and highlight the importance of gastrointestinal health in shaping innate immune cells in the airways and host response to respiratory viruses.
Marisa R. Joldrichsen, Douglas Natoce, R. Woodfint et al.· Journal of Immunology· 0 citations
Findings identify NE as a critical regulator of host immunity and viral replication during SARS-CoV-2 infection and the role played by ELANE in antiviral immunity and disease severity is defined.
Douglas Natoce, Sungjun Yoo, R. Woodfint et al.· Journal of Immunology· 0 citations
It is suggested that commensal microbes-dependent and -independent mechanisms contribute to the difference of outcome after SARS-CoV-2 infection of males and females.
R. Woodfint, Douglas Natoce, Sungjun Yoo et al.· Journal of Immunology· 0 citations
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