Cell-state- and compartment-dependent PI3K/Akt redox signaling in chronic kidney disease: mechanisms and translational implications
Chronic kidney disease (CKD) progression results from coordinated pathological processes across diverse renal cell types and cannot be reduced to extracellular matrix accumulation alone. Tubular stress, disruption of the glomerular filtration barrier, microvascular rarefaction, immune activation, and interstitial remod...