Linking systemic inflammation nutrition status to the tumor immune microenvironment: integrated biomarkers of neoadjuvant response in locally advanced rectal cancer
Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape of colorectal cancer (CRC), yet response remains heterogeneous. The inflammation-nutrition prognostic score (INPS), defined as the neutrophil-to-lymphocyte ratio (NLR) divided by the prognostic nutritional index (PNI), integrates systemic...