Sep 2026
CTRP4 overexpression mitigates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and ferroptosis through activation of the Sirt1-Nrf2 signaling axis.
Collectively, CTRP4 attenuates DOX cardiotoxicity by suppressing oxidative stress and ferroptosis through the Sirt1/Nrf2 axis, highlighting its therapeutic potential for DOX-induced cardiac injury.
Jian Wang, Jie Zhang, Nan Wu et al.
· Biochemical Pharmacology · 0 citations