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Jianwei Che

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Open access Sep 2026

Overcoming EGFR Resistance by Monovalent and Bident Inhibitors Targeting Cys775

Covalent targeting of EGFR cysteine 797 by osimertinib is one of the most successful breakthroughs in targeted therapy, fundamentally transforming the treatment landscape for non-small-cell lung cancer (NSCLC) patients. However, resistance driven by the mutation of C797 remains a major clinical challenge. Developing...

Zheng-Nian Li, Jie Jiang, Ya-Ning Wang et al. · 0 citations
Open access Aug 2026

DCAF11-dependent molecular glue degrader activated by glutathionylation

It is established that metabolically activated compounds can redirect E3 ligase function, thereby expanding the scope of targeted protein degradation and chemically induced proximity.

Hojong Yoon, F. Wachter, Katharine A. Barrett et al. · 1 citation

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