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Author

Jianwei Wang

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Open access Sep 2026

Seasonal influenza vaccine strain selection by quantifying viral fitness

The long-standing challenge of seasonal influenza vaccines providing poor protection is attributed to the rapid and continuous evolution of the virus. In theory, the recommendation of vaccine strain is to predict the dominant strain with best fitness in the upcoming season. Here, we develop FutureFlu, a biologically-gr...

Lu-Yao Qin, Meng-Yi Zhang, Xiao-Yuan Liu et al. · 0 citations
Open access Aug 2026

The EV-A71 RNA-binding protein Matrin 3 facilitates viral replication by stabilizing viral RNA via ZDHHC20-mediated palmitoylation.

A mechanistic pathway by which EV-A71 co-opts MATR3 through condensate formation and palmitoylation to stabilize its genomic RNA and promote viral replication is delineated, and a comprehensive profiling dataset of host proteins associated with EV-A71 RNA is provided.

Xiaoyan Zuo, Yong-Jun Chen, Xia Xiao et al. · 0 citations
Open access Jul 2026

A functional genomics-pharmacotranscriptomics framework identifies host-directed anti-influenza agents

An integrative host-directed drug discovery framework combining functional genomics and pharmacotranscriptomics is developed, providing a systematic and scalable strategy for discovering antivirals that are less susceptible to resistance and potentially applicable to other rapidly evolving pathogens.

Jianfa Qiu, Xuecong Xing, Jing-Feng Wang et al. · 0 citations

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