Author

Jian-Wei Xie

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Aug 2026

Midkine-activated TRPA1+ cancer-associated fibroblasts promote immunotherapy resistance in gastric cancer through a WNT5A-mediated treg circuit

This study unveils an MDK-TRPA1 + CAF-mediated mechanism of ICB resistance in GC and highlights the WNT5A-SPP1+ macrophage pathway as a promising target to overcome immunotherapy resistance.

Hua-Long Zheng, Xiao-Qian Ye, Lin-Yong Zheng et al. · Oncogene · 0 citations

Open access Jan 2026

Multiomics Analysis Reveals CTHRC1+ CAFs Drive Immunosuppressive Niches and Predict Immunotherapy Resistance in Gastric Cancer

These findings establish CTHRC1+ CAFs as a critical stromal determinant of immune exclusion in GC, suggesting that targeting the CTHRC1+ CAF‐MIF axis or applying CRS‐guided patient stratification may enhance immunotherapy efficacy.

Ying-Xin Wu, Ling-han Tang, Ping Li et al. · Human Mutation · 0 citations