Author

Jian-Wei Xu

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Open access Aug 2026

Combined treatment of spinal cord injury using channeled Porous-GelMA scaffold loaded with genetically engineered MSCs expressing inducible ChABC and constitutive BDNF

In vivo studies showed that the BDNF/ChABC-MSCs–CPGS integrated system significantly improved BBB scores, markedly reduced lesion size and collagen deposition, and increased expression of the axonal regeneration markers, NF-H and GAP43, thereby promoting axonal regeneration and functional recovery.

Zhongqing Ji, Jinming Liu, Jian-Wei Xu et al. · Frontiers in Bioengineering... · 0 citations

Open access Aug 2026

Reverse Network Pharmacology-Based Identification of 20-Hydroxyecdysone and Its Inhibition of Glioblastoma Malignant Phenotypes Through the PI3K/AKT Pathway.

BACKGROUND Glioblastoma is the most aggressive primary malignant brain tumor of the central nervous system and remains difficult to treat because of rapid progression, diffuse invasion, and frequent recurrence. This study aimed to identify a potential natural compound against glioblastoma using a reverse network pharma...

Jin-Hui Zhang, Chao Wei, Dong-Yan Wang et al. · Frontiers in Bioscience · 0 citations