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Jian-Xin Wang

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Oct 2026

Complementary Ligand Binding Assay and Intact Mass Spectrometry Strategies for Preclinical Pharmacokinetics of Trispecific Antibody Candidates

Multispecific monoclonal antibodies present bioanalytical challenges for pharmacokinetic (PK) assessment because total concentration measurements alone do not resolve molecular integrity, stoichiometry, or product-related heterogeneity. Here, complementary ligand-binding assay (LBA) and intact liquid chromatography–m...

Jake A. Melby, Erik P. Karmele, Iliana Levesque et al. · 0 citations

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