Author

Jian-Ying Shen

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Open access Oct 2026

Development and validation of an interpretable machine learning model for early prediction of mortality in ICU patients with chronic obstructive pulmonary disease and heart failure

Chronic obstructive pulmonary disease and heart failure frequently coexist, and the mortality risk for patients with these comorbidities is significantly elevated in the intensive care unit (ICU) setting. Therefore, developing an interpretable model for early mortality prediction is crucial to improving the prognosis a...

Jian-Ying Shen, Yu-Cheng Liu, Yi-Kun Chen · Medicine · 0 citations

Open access Sep 2026

Glycyrrhizic acid attenuates sepsis-induced acute lung injury by regulating macrophage M2 polarization via PRKCD

Background Although glycyrrhizic acid (GA) has anti-inflammatory properties and protein kinase C delta (PRKCD) is involved in sepsis, whether GA alleviates sepsis-induced acute lung injury (SI-ALI) by regulating macrophage polarization via PRKCD remains unclear. This study aimed to investigate the protective effects of...

Yi-Kun Chen, Yu-Cheng Liu, Jian-Ying Shen et al. · Journal of Thoracic Disease · 0 citations