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Open access Sep 2026

Sex-specific biological aging clocks across organs and omics

Sex differentially shapes aging, neurodevelopment, and neurodegenerative diseases such as Alzheimer’s disease (AD). Yet, most biological aging clocks (AI-predicted age minus chronological age) were trained on sex-pooled samples and implicitly assume sex invariance. Here, we develop 38 sex-specific biological aging cloc...

Zhi-Yuan Song, Derek Feng, Naowal Azraf Rahman et al. · 0 citations

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