Sep 2026
Synthesis of Axially and Centrally Chiral Alkylidenecyclobutanes Enabled by Catalytic Enantioselective Allylboration
A chiral phosphoric acid catalyzes asymmetric allylboration of stereodefined alkenylcyclobutyl boronates with aldehydes, constructing alcohol-functionalized alkylidenecyclobutanes (ACBs) bearing both axial and central chirality. The reaction proceeds under mild conditions with broad scope, affording products in high...
Kun Liu, Zheng-Han Dong, Dao-Jin Ruan et al.
· Organic Letters · 0 citations