Jianzhong Du

In Situ Engineering Mesenchymal Stem Cells for Osteogenic Differentiation to Reverse Inflammaging and Restore Periodontal Bone Homeostasis

Coordination of Oligonucleotides into Enzyme-Mimetic Nanostructures for Ameliorating Osteoarthritis through Intervening in Articular Cartilage and Subchondral Bone.

Osteoarthritis (OA) is a common degenerative joint disease, characterized by oxidative stress, excessive inflammatory responses, cartilage matrix degradation, and subchondral bone loss. However, a therapeutic strategy that simultaneously addresses these interconnected pathologies remains elusive in current nanomedicine...

Coordinated circRNA Silencing and Chemotherapy by pH-Responsive Nanoparticles Reprogram Cell Death in Drug-Resistant Osteosarcoma.

Chemoresistance remains a major clinical challenge in osteosarcoma, primarily driven by inefficient drug delivery and the evasion of cell death. Here, a multifunctional poly(β-amino ester) (pBAE)-based therapeutic delivery system was developed for simultaneous codelivery of small interfering RNA (siRNA) and doxorubicin...