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Jian-Zhu Zhao

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Review Open access Sep 2026

Cancer Neuroscience: From Local Neuro–Immune Microenvironments to Systemic Brain–Body Circuitry

Classic oncological models have largely restricted cancer pathogenesis to autonomous genetic mutations within localized cells. Current research, however, reframes solid tumors as structurally integrated “pseudo‐organs” that rely on host neural networks for survival. This review examines the reciprocal signaling network...

Ming-Xuan Xie, Yu Zhao, Xin-Ruo Xing et al. · 0 citations
Review Open access Jul 2026

Targeting E3 ubiquitin ligases: Mechanistic breakthroughs and novel clinical translation pathways for tumor radioimmunotherapy

This study focuses on the key roles of E3 ubiquitin ligases in reshaping the immune microenvironment, including the maintenance of spatiotemporal stability of immune checkpoints, the fidelity of antigen processing and presentation, and the epigenetic regulation of microenvironmental dynamic plasticity.

Qian Yang, Xin-Ruo Xing, Yi-Chang Wang et al. · 0 citations

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