Author

Jianan Canal Li

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#small language model Open access Oct 2026

CLEAN Database: providing enzyme function coverage for over 55 million sequences.

Enzyme function annotation is critical for decoding biological systems and enabling rational enzyme design. However, experimentally characterized enzyme functions remain available for only a small fraction of known protein sequences, resulting in a widening gap between rapidly expanding sequence space and reliable func...

Le Yuan, Jianan Canal Li, Miao-Yuan Wen et al. · Nucleic Acids Research · 0 citations

Open access Sep 2026

Predicting genome-wide functional constraints with GPN-Star.

GPN-Star substantially outperforms previous methods in prioritizing pathogenic and fine-mapped genome-wide association study variants, yields strong enrichments of complex trait heritability and improves power in rare variant association testing, which positions GPN-Star as a scalable, powerful and flexible tool for ge...

Cheng-Zhong Ye, Gonzalo Benegas, Carlos Albors et al. · Nature · 4 citations · ⚡1