Oct 2026
Lineage tracing reveals asynchronous fate restriction in mouse embryos and stem cell-derived embryo models
Yun-Zheng Liu, Jihye Park, Laura Amaya et al.
· bioRxiv · 0 citations
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It is revealed that the C-terminal IDR of mammalian ALKBH5 anchors its main activity to mRNA, limiting chromatin engagement in mouse embryonic stem cells, and a conserved role for IDRs in restraining chromatin access by RNA and histone demethylases is uncovered.
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