Author

Jiang-Jiang Qin

2 papers indexed here

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Open access Sep 2026

Epigenetic regulation of NLRP3 by ACLY–PLAC8 axis sustains metabolic adaptation in triple-negative breast cancer

Cell metabolism is intricately interconnected with various pathological processes, including metabolic disorders, chronic inflammation, and tumor progression. Dysregulated lipid metabolism can result in mitochondrial dysfunction and excessive reactive oxygen species accumulation, which are well-established triggers f...

Mi-Sha Mao, Hao-Tian Liu, Jiang-Jiang Qin et al. · Cell Death & Disease · 0 citations

Open access Sep 2026

Targeting CTGF+ cancer-associated fibroblasts disrupts tumor-stroma crosstalk in pancreatic ductal adenocarcinoma.

Targeting CTGF+ CAFs with QX03-46 significantly disrupted the CTGF/TGF-β1 signaling axis and suppressed CAF functions, resulting in decreased extracellular matrix deposition and oncogenic cytokine secretion and position QX03-46 as a promising therapeutic candidate for targeting the fibrotic TME.

Yi-Wen Shen, Qing-Yan Sun, Yunzhe Wang et al. · Proceedings of the National... · 0 citations