Author

Jiang Lei

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Open access Oct 2026

Dual-Axis Pattern of Peripheral Immunity in Myasthenia Gravis Susceptibility: A Prospective Cohort Study and Mendelian Randomization Analysis

Background: Previous studies have revealed peripheral immune abnormalities in myasthenia gravis (MG). However, it remains uncertain whether these abnormalities precede the onset of clinical symptoms and affect susceptibility to MG. Methods: A prospective study was performed involving 420,936 UK Biobank participants wit...

Jiang Lei, Hao Huang, Jia-Xin Chen et al. · Biomedicines · 0 citations

Open access Oct 2026

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

ABSTRACT Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons in the substantia nigra, with mitochondrial dysfunction central to its pathology. Recent studies have linked lactate—accumulating in PD due to mitochondrial dysfunction—to disease mechani...

Ying-Yao Liu, Xi Li, Wen-Xuan He et al. · Advancement of science · 0 citations

Open access Jul 2026

Serum total cholesterol and low-density lipoprotein cholesterol are associated with Parkinson’s disease in East Asian populations: a bidirectional Mendelian randomization study with complementary animal observation

Genetic evidence supporting a genetically predicted inverse association of TC and LDL-C with PD risk among East Asian populations is provided, and the underlying mechanisms and any therapeutic implications warrant further experimental investigation.

Yan-Zi Bao, Hua-Xin Huang, Wei Feng et al. · Frontiers in Aging Neuroscie... · 0 citations