C-terminus of HSC70-Interacting Protein-Mediated Transforming Growth Factor-β 1 Protein Degradation Underlies the Anti-fibrotic Effects of Verbascoside in Pulmonary Fibrosis.
BACKGROUND Pulmonary fibrosis (PF) is a progressive and fatal interstitial lung disease with limited therapeutic options. Transforming growth factor-β1 (TGF-β1) is a master driver of fibrogenesis, but strategies to effectively degrade this protein remain underexplored. Verbascoside, a natural phenylethanoid glycoside,...