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Jiangtao Gou

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Open access Sep 2026

Sample size estimation for a flexible phase II oncology trial design using two dependent endpoints with nested response metrics.

A flexible phase II design framework for two primary endpoints with nested response metrics is developed and the Holm-type and Holm-type designs can reduce the required sample size while maintaining prespecified error-rate and power requirements.

Jiangtao Gou, F. Zhang · 0 citations

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