Open access
Sep 2026
Sample size estimation for a flexible phase II oncology trial design using two dependent endpoints with nested response metrics.
A flexible phase II design framework for two primary endpoints with nested response metrics is developed and the Holm-type and Holm-type designs can reduce the required sample size while maintaining prespecified error-rate and power requirements.
Jiangtao Gou, F. Zhang
· Contemporary Clinical Trials · 0 citations