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Jian-Lin Wu

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Oct 2026

Analysis of molecular events triggered by furanocoumarins in Psoralea corylifolia L. via reactive metabolites and protein adducts.

ETHNOPHARMACOLOGICAL RELEVANCE Psoralea Fructus (PF), the dried ripe fruit of Psoralea corylifolia L., is a widely utilized Chinese medicinal herb with a long-established history in clinical practice and is known for its diverse biological activities. Although furanocoumarin is potentially hepatotoxic, exposure levels...

Shan Han, Zhen-Dong Wang, Li-Wen Zhang et al. · 0 citations
Open access Jul 2026

Structure-Based Design of New Nonpeptidic Covalent Mpro Inhibitors against SARS-CoV-2 and Omicron Variants

The structure-based covalent modifications that generate new nonpeptidic covalent Mpro inhibitors are described that may support the deuterated compound as a new lead for developing anti-SARS-CoV-2 drugs and further reveal the feasibility of using chloroacetyl for structure-based covalent drug design.

Honglei Bao, Ling-Chen Sun, Shi-Lin Gong et al. · 0 citations
Aug 2026

Electrostatic bridge-induced aggregation of silver nanoclusters for turn-on Mn2+ detection and luminescent film fabrication.

In this work, red-fluorescent silver nanoclusters (MMTA@Ag NCs) with aggregation-induced emission (AIE) properties were synthesized via a facile one-pot strategy at room temperature using 2-mercapto-4-methyl-5-thiazoleacetic acid (MMTA) as the capping ligand. The as-prepared Ag NCs initially exhibited weak fluorescence...

Peng-Fei Gao, Bing Han, Guo-Mei Zhang et al. · 0 citations
Review Aug 2026

Engineering Advanced Nanomedicine Against Depression: From Treatment Challenges to Delivery Strategies.

By moving beyond generic strategies for BBB penetration to address the distinctive pharmacotherapeutic shortcomings of depression, engineered nanomedicine holds great promise for advancing next-generation antidepressant therapies that achieve rapid onset, precise intervention, and comprehensive improvement in patient q...

Mijia Zhang, En-Yao He, Y. Xiong et al. · 0 citations

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