Echinococcus granulosus antigen 5: a novel immunomodulator that targets NF-κB signaling to suppress inflammation in THP-1 monocyte.
Chronic infection by Echinococcus granulosus leads to the establishment of fluid-filled cysts (hydatid cysts) in the liver or lungs of infected hosts, which can escape destruction by the host immune system for long periods. Ag5 is abundantly expressed in the cyst fluid of the fine-grained E. granulosus and plays an imp...