Design, Synthesis, and Antifungal Activity of Novel Oxadiazole-Pyrazole-Triazole Derivatives: Insights into Cellular Disruption Revealed by Integrated Transcriptomic and Proteomic Analyses.
Mechanistic investigations revealed that L22 induces severe cellular disruption, characterized by compromised membrane integrity, cell wall deformation, and broad dysregulation of sterol/lipid metabolism, carbohydrate utilization, mitochondrial respiration, and stress-response pathways, warranting further development f...