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Oct 2026

Association of Skin Denervation With Brain Atrophy and Cognitive Impairment in Patients With Parkinson Disease.

BACKGROUND AND OBJECTIVES Small fiber pathology is an intrinsic feature of Parkinson disease (PD), yet its relevance to central neurodegeneration remains unclear. Given that cognitive impairment is a major manifestation of disease progression closely linked to cortical structural changes, we aimed to determine whether...

Ming-Lei Liu, Tian-Yuan Yang, Lan-Jun Li et al. · 0 citations
Aug 2026

NRN1 inhibits neuronal apoptosis and improves motor recovery after spinal cord injury via binding to FZD2 to activate the GSK-3β/Nrf2 pathway.

Neuritin 1 (NRN1) is a neurotrophic factor known to protect neurons from damage and cell death; however, its role and mechanism in cervical spinal cord injury (CSCI) remain unclear. In this study, we investigated the function of NRN1 using oxygen-glucose deprivation (OGD)-treated PC12 cells and a rat model of CSCI esta...

Yan-Fei Chen, Jiao Hao, Chenyang Shui · 0 citations

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