Msx1 orchestrates retinal progenitor cell homeostasis from mechanical locking to synthetic arrest through the PI3K/AKT/mTOR pathway.
Despite the known association between the muscle segment homeobox 1 (Msx1) gene and neural diseases, its function in maintaining homeostasis in adult retinal progenitor cells (RPCs) unclear. We using an in vitro adult RPC model combined with short hairpin RNA-mediated knockdown, RNA sequencing, and tandem mass tag -bas...