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Author

Jiao Meng

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Oct 2026

AAV-mediated Siglecf elimination on TAMs reverses TMZ therapy-induced T cell dysfunction in glioblastoma.

Glioblastoma (GBM) is the most aggressive primary tumor of the brain, characterized by extensive intratumor heterogeneity, and exhibits inevitable recurrence despite conventional therapy. This study investigates the immunosuppressive mechanisms underlying GBM recurrence following temozolomide (TMZ) therapy, with a spec...

Zhen-Kun Yang, Jie Li, Da-Xing Xu et al. · 0 citations
Open access Aug 2026

Integrated single-cell and experimental analyses implicate GPRC5B in macrophage senescence-related alterations in postmenopausal osteoporosis

GPRC5B is a macrophage-enriched, PMO-associated candidate identified through integrated transcriptomic analyses and supported by preliminary functional experiments, suggesting that GPRC5B may participate in macrophage-related alterations in PMO and warrant further mechanistic and translational investigation.

Shi-Zhou Zhao, Yi-Xing Yang, Jiao Meng et al. · 0 citations

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