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Author

Jiao Wu

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Review Oct 2026

Nanomatrix engineering for LDI-MS based biomedical metabolomics.

Metabolomics provides functional molecular readouts of disease phenotypes, therapeutic responses, and tissue microenvironments, but its extension to low-volume, single-cell, and spatially resolved samples remains analytically challenging. Laser desorption/ionization mass spectrometry (LDI-MS) offers a rapid, direct, an...

Yi Gu, Yan-Xi Yang, Jiao Wu et al. · 0 citations
Open access Sep 2026

Plasma metabolic fingerprinting identifies phenylalanine as a mortality biomarker in elderly ARDS patients

Currently, there remains a lack of effective prognostic biomarkers specifically for ARDS patients. We conducted a retrospective study profiling plasma metabolomics (ARDS = 55, non-ARDS = 37) via high-throughput NPELDI-MS. Machine learning (LR, SVM, NN) developed age-stratified prognostic models (< 65 vs. ≥...

Yan-Yan Li, Jing Xu, Bo-Shun Zhang et al. · 0 citations

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