Author

Jiaoe Chen

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Open access Jan 2026

GPR39 Suppresses Ferroptosis via the Nrf2/SLC7A11 Axis and Reduces the Sensitivity of Colorectal Cancer to Anti‐PD‐1 Immunotherapy

In vivo, GPR39 knockdown significantly potentiated the antitumor activity of PD‐1 blockade, as evidenced by suppressed tumor progression accompanied by enhanced infiltration of CD8+ T cells, whereas ferroptosis inhibition abrogated these effects.

Cong Zhou, Xiao-Ling Fang, Jia-Ying Lin et al. · Canadian Journal of Gastroen... · 0 citations

Open access Jul 2026

Lachnospiraceae and Its Metabolite Malate Act in Concert to Repair Gut Microbiota Imbalance and Block Colorectal Cancer Progression.

Lachnospiraceae bacterium biologics abstracts accession-2278 (BAA-2278) is associated with anti-CRC effects in preclinical models, potentially mediated through regulation of gut microbiota homeostasis and inhibition of Wnt/β-catenin signaling via its metabolite malate.

Ze-Jun Fang, Yan-Yan Hu, Min-Jing Zhu et al. · Frontiers in Bioscience · 0 citations