Perineural invasion (PNI), the infiltration of nerves by tumor cells, is a hallmark of pancreatic ductal adenocarcinoma (PDAC); however, despite being a clinically relevant phenomenon, the mechanisms underlying PNI remain poorly understood. Most currently available in vitro and ex vivo models rely on murine-sourced n...
Regina A. Casimiro-Núñez, Sydney Willey, Harrison L. Hiraki et al.· Cancer Research· 0 citations
This work investigated how KMT2D loss rewires enhancer accessibility and transcription factor networks to promote EMP in PDAC and identified an important mechanism underlying the tumor suppressive role of KMT2D in PDAC.
Raghunath Ranga Sudharshan, H. Kim, Heizel Acosta et al.· Cancer Research· 0 citations
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies and is characterized by a profoundly immunosuppressive tumor microenvironment (TME) that limits the efficacy of current therapies. KMT2D (Mll4 in mice) is a histone H3K4 methyltransferase and critical epigenetic regulator that is altere...
Heizel Acosta, R. Sudharshan, Hongsun C. Kim et al.· Cancer Research· 0 citations
KMT2D plays a pivotal role in orchestrating both tumor-intrinsic and microenvironmental processes that drive pancreatic cancer progression, and understanding how KMT2D loss reprograms the immune landscape may uncover novel immunomodulatory therapeutic targets for pancreatic cancer.
H. Acosta-Vilanova, H. Kim, Shungang Zhang et al.· Journal of Immunology· 0 citations
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