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Author

Jiayi Lu

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Open access Aug 2026

Characterizing and mitigating cross-library PCR chimeras in Perturb-seq using Perturb-Audit

Perturb-Audit, a diagnostic and denoising framework that integrates molecule-level collision auditing with statistical background suppression, supports an audit-first strategy to improve assignment fidelity and biological interpretability in single-cell CRISPR screens.

Xin Song, Jiayi Lu, Ping Zhu · 0 citations