Microplastics (MPs) and nanoplastics (NPs) are ubiquitous contaminants in dietary sources, including seafood, table salt, infant formula, and drinking water. Recent stimulated Raman scattering microscopy has reported approximately 2.4 × 105 MPs and NPs per liter in selected bottled-water samples. While these estimates...
Fei-Yu Xu, Yu-Jian Fan, Xiao-Kai Guo et al.· Comprehensive Reviews in Foo...· 0 citations
Immune checkpoint inhibitors and adoptive cell therapies have revolutionized cancer treatment, yet their success is accompanied by immune-related hepatotoxicity that can range from asymptomatic enzyme elevation to life-threatening liver failure. Unlike conventional drug-induced liver injury, immune-mediated hepatotoxic...
Yu-Jian Fan, Xiao-Kai Guo, Jiaying Lyu et al.· Medicinal research reviews (...· 0 citations
A mechanistic analysis of pharmaceutical ecotoxicity demonstrates that effective intervention requires targeting root causes across the pharmaceutical lifecycle rather than relying on end-of-pipe remediation, and that integrating environmental sustainability into pharmaceutical safety assessment is essential for protec...
Yu-Jian Fan, Xiao-Kai Guo, Jiaying Lyu et al.· Ecotoxicology and Environmen...· 0 citations
An integrated risk assessment framework is proposed that combines adverse outcome pathway analysis, physiologically-based pharmacokinetic modeling, new approach methodologies, and safe-by-design principles to enable predictive hazard identification and supports evidence-based regulation of existing ENMs while enabling...
Yu-Jian Fan, Jiaying Lyu, Xiao-Kai Guo et al.· Journal of materials chemist...· 0 citations
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