Spatial perturbation profiling is becoming an important tool in functional genomics because it reveals how genetic interventions reshape transcription within intact tissue contexts. However, destructive readout and limited screening capacity leave many perturbation-by-location response profiles unmeasured, motivating t...
Hong-Min Cai, Wanghou, Jiazhou Chen et al.· bioRxiv· 0 citations
Spatial transcriptomics (ST) enables the simultaneous measurement of high-throughput gene expression and spatial structural information, offering a powerful means to decipher tissue heterogeneity. However, current spatial domain identification methods struggle to accurately distinguish continuous biological boundaries,...
Jiazhou Chen, Ziru Xiao, Junyu Li et al.· Proceedings of the 32nd ACM...· 0 citations
Morph-ISR is proposed, a morphology-aware implicit super-resolution framework for DP that restores diagnostically relevant details with sub-pixel precision and enhances structural fidelity, demonstrating superior preservation of diagnostically relevant cellular boundaries and nuclear textures.
Jia-Ming Liang, Qihui Han, Hao-Lin Chen et al.· 0 citations
Spatial transcriptomics (ST) enables the simultaneous measurement of high-throughput gene expression and spatial structural information, offering a powerful means to decipher tissue heterogeneity. However, current spatial domain identification methods struggle to accurately distinguish continuous biological boundaries,...
Jiazhou Chen, Ziru Xiao, Junyu Li et al.· Proceedings of the 32nd ACM...· 0 citations
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