Review
Open access
Aug 2026
Non-histone protein L-lactylation in cancer: a metabolic switch for immune evasion and therapeutic resistance
This work defines the spatially compartmentalized catalytic network governing this process, detailing how nuclear EP300/CBP, cytosolic AARS1, and mitochondrial AARS2 mediate stereospecific targeted modifications.
Ying-Ying Guo, Lanyang Gao, Shundan Li et al.
· Molecular Cancer · 0 citations