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Open access Sep 2026

Glutamatergic Dysregulation in Depression, Schizophrenia, and Addiction: Mechanisms and Therapeutic Strategies

Glutamate, the principal excitatory neurotransmitter in the brain, plays a central role in neurotransmission, synaptic plasticity, and cognitive function. Dysregulation of glutamatergic signaling is implicated in depression, schizophrenia (SCZ), and addiction. N-methyl-Daspartate receptor/α-amino-3-hydroxy-5-methyl-4-...

Wen-Jing Shi, Jie Bai · 0 citations

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