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Oct 2026

Stigmasterol suppresses macrophage-mediated inflammatory amplification in acute pancreatitis through PPAR-γ-dependent macrophage reprogramming.

ETHNOPHARMACOLOGICAL RELEVANCE Glycine max (L.) Merr. (G. max; soybean), a widely cultivated medicinal and edible plant, has been traditionally used in Chinese medicine and dietary practices for maintaining digestive health. Stigmasterol (STG), a naturally occurring dietary phytosterol widely distributed in G. max and...

Xin Zeng, Jie Chen, Ke-Yi Yang et al. · 0 citations
Open access Sep 2026

Redox-neutral synthesis of azepane-fused spiroindolenines via Sc(OTf)3-catalyzed cascade [1,5]-hydride transfer/cyclization

Herein, we report the first Sc(OTf)3-catalyzed redox-neutral cascade [1,5]-hydride transfer/cyclization for the efficient synthesis of azepane-fused spiroindolenines. This structurally strained seven-membered-ring scaffold has long eluded efficient access. The reaction proceeds via Knoevenagel condensation, intramolecu...

Li-Wen Zhang, Jie Chen, Guo Tang et al. · 0 citations

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