Author

Jie Gu

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Open access Oct 2026

Macrophage- or neutrophil-expressed UPP1 drives tumor growth and immune suppression in the tumor microenvironment

Uridine phosphorylase 1 (UPP1) has recently emerged as a metabolic regulator with critical roles in tumor cell biology. However, its expression pattern and functional significance in nonmalignant components of the tumor microenvironment (TME) remain largely unexplored. Here, we performed a comprehensive pan-cancer sing...

Yin Li, Qin Ran, An-Ying Xiong et al. · Science Advances · 0 citations

Jul 2026

Spatiotemporal multiomics uncover tumor ecosystem dynamics during metastatic colonization.

A residual population of quiescent Phgdhhigh DTCs that survived initial innate immune clearance and became transiently enriched in micrometastases are identified, providing insights into the development of micrometastasis-targeting regimens.

Yun-Fan Sun, Y. Zhong, Shang Liu et al. · Science · 0 citations