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Oct 2026

SPP1+ TAMs drive colorectal tumorigenesis through an ARG2-orchestrated metabolic-immune crosstalk.

Rising incidence of colorectal cancer (CRC) and limited therapeutic options highlight the urgent need to define the drivers of its progression. The SPP1+ tumor-associated macrophage (TAM) subset identified by single-cell transcriptomics is a functionally dominant population that extends beyond the classical M1/M2 parad...

Lin-Hong Song, T. Yan, Shi-Yuan Lu et al. · 0 citations

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