Expanding the phenotype of hereditary renal cell carcinoma syndromes: Implications for surveillance and management.
BACKGROUND Approximately 5% of renal cell carcinoma (RCC) occurs in the setting of a hereditary RCC syndrome, but accurate phenotype and cancer risk estimates remain limited by ascertainment bias in reported series. METHODS We analyzed 32,728 cancer patients who underwent paired tumor-normal sequencing with MSK-IMPAC...