Author

Jie Lu

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Open access Sep 2026

Beyond statistical thresholds: Mapping sequential ATN cascade transitions via brain structural topography in Alzheimer’s disease

Alzheimer’s disease is widely conceptualized as a biological continuum initiated by amyloid-β (Aβ) accumulation, followed by tau aggregation and neurodegeneration. Although the ATN framework is commonly used to define disease stages, its static biomarker categories may not fully capture the dynamic pathological transit...

Dong Wang, Shao-Zhen Yan, Rong-Shen Zhou et al. · Science Advances · 0 citations

Aug 2026

Multimodal PET Imaging Unveils Early Metabolic Compensation Mechanisms and Dopaminergic Degeneration in Parkinson’s Disease

Multimodal PET imaging reveals dynamic interactions between cerebral glucose metabolism and dopaminergic degeneration in Parkinson’s disease, highlighting cerebellar-pontine hypermetabolism as a compensatory response to nigrostriatal degeneration.

Shuang Li, Wei-Zhao Lu, Shao-Zhen Yan et al. · Cerebellum · 0 citations

Open access Jul 2026

Striatal Tau Pathology Underlies Monoaminergic Disruption in Progressive Supranuclear Palsy

The pallido-nigro-luysian axis and nigrostriatal system serve as sensitive targets for detecting tau deposition and monoaminergic disruption in PSP and local striatal tau pathology and tau burden were associated with monoaminergic disruption in PSP.

Chong Dong, Jing-Hong Ma, Hong-Gang Qiao et al. · Clinical Nuclear Medicine · 0 citations