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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Jie Ma

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Open access Oct 2026

Extracellular lactate enhances IL-10 transcription via H4K5 lactylation and promotes an A2-like reactive-astrocyte phenotype after ischemic stroke.

BACKGROUND Ischemic stroke triggers a rapid rise in lactate levels in the brain tissue. The neuroprotective role of exogenous lactate administered during the reperfusion phase has recently garnered attention. A neuroprotective A2 phenotype of reactive astrocytes (RACs) is characterized by interleukin-10 (IL-10) upregul...

Jun-Yuan Wei, Yu-Meng Si, Ji Li et al. · 0 citations
Open access Aug 2026

Integration of Spatial Transcriptomics and Mendelian Randomization Identifies Candidate Molecular Regulators of Endometrial Cancer Progression

Highlights What are the main findings? MM0 was identified as a putative stemness-associated malignant epithelial transcriptional subpopulation, and MM0-enriched regions showed higher inferred JAK–STAT and hypoxia scores in the cross-sectional spatial analysis. Integrative Mendelian randomization and colocalization anal...

Jia-Nan Zhao, Xiao-Nan Liu, Hui-Yang Zhao et al. · 0 citations

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