Open access
Sep 2026
Intermedin mitigates chronic intermittent hypoxia-induced metabolic reprogramming in tubular epithelial cells and attenuates consequent kidney fibrosis through an AMPK-dependent suppression of HIF-1α.
It is demonstrated that IMD alleviates CIH-induced metabolic reprogramming in TECs and curbs kidney fibrosis via AMPK activation and consequent HIF-1α signaling, indicating that IMD suppresses HIF-1α through an AMPK-dependent mechanism.
Yuan Ge, Juan Pan, Ya-Nan Li et al.
· Free Radical Biology & Medic... · 0 citations