A system pharmacology framework to explore the therapeutic mechanism of Bushen-Yizhi formula against Alzheimer’s disease via integrating UPLC-Q-TOF-MS/MS, network analysis, machine learning and experimental validation
Alzheimer’s disease (AD) is an incurable neurodegenerative disease, and Bushen-Yizhi formula (BSYZ) has shown clinical potential for AD treatment, yet its bioactive components and pharmacological mechanisms remain unproven. To explore the therapeutic mechanism of BSYZ against AD-like cognitive impairment, a syste...